IL-10 sequence variants are disclosed that retain the therapeutically desirable anti-inflammatory properties of wild-type IL-10 but do not retain the hemoatopoeitic cell regulatory and cell proliferative activities. The mutant IL-10 polypeptides of the invention are used in methods of treating diseases involving inflammatory response, including neuropathic pain and other neurological disorders.
申请公布号
WO2006130580(A2)
申请公布日期
2006.12.07
申请号
WO2006US20863
申请日期
2006.05.26
申请人
AVIGEN, INC.;THE REGENTS OF THE UNIVERSITY OF COLORADO;SOMMER, JURG M.;CHAVEZ, RAYMOND A.;JOHNSON, KIRK W.;WATKINS, LINDA MAY ROTHBLUM
发明人
SOMMER, JURG M.;CHAVEZ, RAYMOND A.;JOHNSON, KIRK W.;WATKINS, LINDA MAY ROTHBLUM
