发明名称 |
BICYCLIC DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH |
摘要 |
The invention relates to substantially pure compounds of the formula (1): and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>3</SUP>, R<SUP>5</SUP>, and X are as defined herein, and wherein the compound of formula (1) optionally further comprises a hydroxy substituent, an O-glucuronic acid, or an N->O (N-oxide) moiety. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula (1) and to pharmaceutical compositions for treating such disorders that contain the compounds of formula (1). The invention also relates to methods of preparing the compounds of formula (1). |
申请公布号 |
WO2006129168(A2) |
申请公布日期 |
2006.12.07 |
申请号 |
WO2006IB01408 |
申请日期 |
2006.05.22 |
申请人 |
PFIZER PRODUCTS INC.;BHATTACHARYA, SAMIT, KUMAR;PRAKASH, CHANDRA, AGGARWAL |
发明人 |
BHATTACHARYA, SAMIT, KUMAR;PRAKASH, CHANDRA, AGGARWAL |
分类号 |
C07D401/12;A61K31/517;A61P35/00 |
主分类号 |
C07D401/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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