发明名称 |
MULTISPECIFIC BINDING MOLECULES COMPRISING CONNECTING PEPTIDES |
摘要 |
Multispecific binding molecules comprising synthetic connecting peptides. The synthetic connecting peptides result in the preferential synthesis of multispecific binding molecules comprising polypeptide chains that are linked via at least one interchain disulfide linkage. Compositions in which a majority of the multispecific binding molecules comprising polypeptide chain that are linked via at least one interchain disulfide linkage or are not linked via at least one intrachain disulfide linkage. A specific embodiment pertains to compositions comprising multispecific dimeric binding molecules said molecules comprising at least a first binding site specific for a tumor necrosis factor (TNF) receptor or a ligand of a TNF receptor family member and at least a second binding site; and at least two polypeptide chains comprising at least one heavy chain portion and a synthetic connecting peptide; wherein greater than about 50% of the dimers comprise polypeptide chains that are linked via at least one interchain disulfide linkage. |
申请公布号 |
WO2006074399(A3) |
申请公布日期 |
2006.12.07 |
申请号 |
WO2006US00505 |
申请日期 |
2006.01.05 |
申请人 |
BIOGEN IDEC MA INC.;GLASER, SCOTT;WU, XIUFENG |
发明人 |
GLASER, SCOTT;WU, XIUFENG |
分类号 |
A61K39/395;A61P35/00;C07K16/28;C07K16/46;C12N5/10;C12N15/13;C12N15/62;C12N15/85 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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