METHODS AND APPARATUS FOR ULTRASONICALLY INCREASING THE TRANSPORTATION OF THERAPEUTIC SUBSTANCES THROUGH TISSUE

摘要

The transportation of therapeutic substances through internal tissue is enhanced by surgically implanting an ultrasound transducer in immediate proximity to the target tissue and oriented to direct ultrasound having selected characteristics toward the target tissue. The parameters of frequency, mechanical index, pulses per cycle and pulse repetition frequency are selected within defined ranges to cause molecules to be transported at a rate and over a distance substantially greater than by natural diffusion.