COAGULATION FACTOR X POLYPEPTIDES WITH MODIFIED ACTIVATION PROPERTIES
摘要
The present invention relates to modified cDNA sequences coding for human Factor X and their derivatives with improved stability and modified activation sequences, recombinant expression vectors containing such cDNA sequences and host cells transformed with such recombinant expression vectors. The invention also relates to recombinant factor X polypeptides and derivatives which do have biological activities of the unmodified wild type protein but with improved stability and processes for the manufacture of such recombinant proteins and their derivatives. The invention also covers a transfer vector for use in human gene therapy, which comprises such modified DNA.
申请公布号
WO2006128668(A2)
申请公布日期
2006.12.07
申请号
WO2006EP05131
申请日期
2006.05.30
申请人
ZLB BEHRING GMBH;SCHULTE, STEFAN;HAUSER, HANS-PETER;KALINA, UWE;WEIMER, THOMAS
发明人
SCHULTE, STEFAN;HAUSER, HANS-PETER;KALINA, UWE;WEIMER, THOMAS