a, ß-UNSATURATED ESTERS AND ACIDS BY STEREOSELECTIVE DEHYDRATION

摘要

There are provided by the present invention certain pyrazole based CCK-1 receptor modulators which have the general formula: wherein Ar is an aromatic or heteroaromatic group, X is a hydrocarbon linker, Y is a bond or hydrocarbon linker and R¹, R², R³, R⁴ and R⁵ are certain organic substituents, methods for making the same, and stereoselective dehydration methods for generally making a,ß-unsaturated esters, acids and their derivatives.