| 摘要 |
The present invention relates to a polyclonal antiserum against a universal tumor antigen obtainable by (i) eliciting an in vivo humoral response against embryonic tissue in a non-human vertebrate, whereby said embryonic tissue is of the same genetic line as the non-human vertebrate; (ii) recovering from the immunized non-human animal spleen and isolating from said spleen individual spleen cells/lymphocytes; (iii) eliciting a second in vivo humoral response to the isolated spleen cells/lymphocytes suspension obtained in step (ii) in a further non-human animal of the same genetic line as the non-human animal of step (i); and (iv) isolating the desired polyclonal antiserum from said animal. Furthermore, the invention provides for the use of the polyclonal antiserum for the preparation of a pharmaceutical composition for the amelioration, prevention and/or treatment of cancer, in particular cancer of the breast, lung, prostate, uterus, colon, stomach or bladder. Additionally the invention relates to the use of the polyclonal serum of the invention for the preparation of a pharmaceutical composition, wherein said pharmaceutical composition is to be administered to a subject in need of treatment in combination with a further anti-proliferative drug or medicament.
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