| 发明名称 |
Protein based tumor necrosis factor-receptor variants for the treatment of TNF related disorders |
| 摘要 |
The invention relates to novel proteins with TNF-receptor antagonist activity and nucleic acids encoding these proteins. The invention further relates to TNF-receptor proteins with reduced immunogenicity and the use of these novel proteins in the treatment of TNF related disorders.
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| 申请公布号 |
US7144987(B1) |
申请公布日期 |
2006.12.05 |
| 申请号 |
US20030336242 |
申请日期 |
2003.01.03 |
| 申请人 |
XENCOR |
发明人 |
CHIRINO ARTHUR J.;LUO PEIZHI;MCDONNELL PETER COLON;MUCHHAL UMESH;TANSEY MALU LOURDES |
| 分类号 |
C07K17/00;C12N15/09;A61K38/00;A61K38/19;A61P19/00;A61P29/00;C07K14/52;C07K14/525;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/00;C12N15/28;C12P21/02 |
主分类号 |
C07K17/00 |
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