Thrombin inhibitors

摘要

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure Formula (I): wherein u is CH or N; Q is 1)-N(R²⁵)CH(R³⁰)- wherein the nitrogen atom is attached to R¹, and R²⁵ and R³⁰ are independently selected from the group consisting of hydrogen, C_3-6cycloalkyl, and C_1-6alkyl, or 2) wherein the nitrogen atom is attached to R¹, and m is 0, 1, or 2