| 摘要 |
The subject invention provides compounds having the structure: wherein R<SUB>1 </SUB>is H, OH, a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety; R<SUB>2 </SUB>is H, OH, a photoactivatable moiety, a fluorescent-moiety, or a radioactive moiety; R<SUB>3 </SUB>is H or OH; R<SUB>4 </SUB>is H, OH, a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety; and wherein at least one of R<SUB>1</SUB>, R<SUB>2</SUB>, R<SUB>3</SUB>, or R<SUB>4 </SUB>is a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety, or an optically pure enantiomer of the compound or wherein R1 is H or OH; R2 is H, OH, halogen, unsubstituted or substituted, straight or branched (C<SUB>1</SUB>-C<SUB>5</SUB>) alkyl group, (C<SUB>2</SUB>-C<SUB>5</SUB>) alkenyl, or a (C<SUB>2</SUB>-C<SUB>5</SUB>) alkynyl, (C<SUB>1</SUB>-C<SUB>5</SUB>) alkoxy, (C<SUB>2</SUB>-C<SUB>5</SUB>) alkenyloxy, or (C<SUB>2</SUB>-C<SUB>5</SUB>) alkynyloxy, -N3, -COR5, -CONR5R6, -CO2R5, -OCOR5, -NH(OH), -NR5R6, -NHCOR5, -N(OH)COR5, -CH2OR5, -OCH2CO2R5, -CH2SR5, -CH2NR5R6, -SR5, -OSR5, or -NR5SO2R6, where R5 and R6 are each independently hydrogen, substituted or unsubstituted (C<SUB>1</SUB>-C<SUB>5</SUB>) alkyl, (C<SUB>2</SUB>-C<SUB>5</SUB>) alkenyl, or (C<SUB>2</SUB>-C<SUB>5</SUB>) alkynyl, or a cycloalkyl or aryl group having 3 to 10 carbon atoms; R3 is H or OH; R4 is H, (C1-C10) alkyl, (C1-C10) alkenyl, (C1-C10) alkynyl, -A-Ar, -A-Z-Ar, -SO<SUB>2</SUB>-Ar, or -A-NR<SUB>5</SUB>, or -R<SUB>7</SUB>, where A, Z and Ar are as defined herein, and the use of the compounds for detecting or identifying a receptor which binds the compounds of the invention or for treating a PAF associated condition in a subject. |
