| 摘要 |
The invention discloses a method and an apparatus for exact metering and volumetric filling of dry powder medicament doses into preformed containers, which are adapted for administration by means of a dry powder inhaler (DPI). The filling apparatus of the invention includes at least a bulk powder source (401), a feeding chamber (134) and a receptacle (110) providing the volume for a specified load mass (202) of dry powder. The bulk powder source releases a portion of powder discontinuously to the feeding chamber, but is disconnected from the feeding chamber and receptacle during the filling operation. The filling apparatus further presents a plane surface (103) in contact with the movable feeding chamber and provides a hard-wearing, low friction coating for reducing dynamic friction and powder retention. |
