| 摘要 |
Consistent with an aspect of the present invention, a mixing apparatus is provided which can combine or mix relatively large amounts of solid and liquid ingredients with minimal exposure to undesired impurities. The mixing apparatus includes a hermetically sealed chamber, such as a glove box, for receiving the solid ingredient. The solid ingredient may then be passed from the glove box, through a funnel located therebeneath, to a disperser. The disperser is also closed to the atmosphere, and is configured to mix the liquid and solid ingredients. Since the ingredients are not exposed to air prior to and during the mixing process, little or no contamination occurs. The mixing apparatus consistent with the present invention is particularly suited for manufacturing tigecycline.
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