摘要 |
PROBLEM TO BE SOLVED: To find out a useful compound as a drug for curing corneal and conjunctival diseases among many known biphenylmethyl derivatives. SOLUTION: A compound represented by general formula (1) or its salt has an excellent effect of improving in a model of corneal diseases and is useful as a drug for curing corneal and conjunctival diseases such as dry eye, corneal ulcer, corneal inflammation, conjunctival inflammation, punctate superficial keratitis, corneal epithelial defect, conjunctival epithelial defect, dry keratoconjunctivitis, upper part keratoconjunctivitis and filamentary corneal inflammation. In general formula (1), ring Y indicates a substituted or unsubstituted heterocycle containing nitrogen; R<SP>1</SP>indicates a carboxyl group or a substituted or unsubstituted five-membered nitrogen-containing heterocycle; and R<SP>2</SP>and R<SP>3</SP>may be the same or different and indicate each a hydrogen atom, a substituted or unsubstituted alkyl group or a substituted or unsubstituted alkylcarbonyl group. COPYRIGHT: (C)2007,JPO&INPIT
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