COMBINATION DRUG

摘要

It is intended to provide a combination drug of a five-membered cyclic compound with a steroid drug or a steroid combination for asthma, rhinitis, sinusitis or a chronic obstructive pulmonary disease, which is a therapeutic pharmaceutical composition for asthma, rhinitis, sinusitis or a chronic obstructive pulmonary disease, characterized in that a pharmaceutical composition containing a five-membered cyclic compound represented by the formula (1): [wherein X represents an oxygen atom or a sulfur atom; R<SUP>1</SUP> represents a hydrogen atom, substituted or unsubstituted alkyl or the like; R<SUP>2</SUP> represents a hydrogen atom, substituted or unsubstituted alkyl or the like; Y<SUP>1</SUP> represents a single bond, substituted or unsubstituted alkylene or the like; the wavy line means either (E)- or (Z)-coordination; R<SUP>3</SUP> represents a hydrogen atom, substituted or unsubstituted aryl or the like; Y<SUP>2</SUP> represents substituted or unsubstituted alkylene or alkenylene; R<SUP>4</SUP> represents a hydrogen atom, substituted or unsubstituted alkanoyl or the like; and R<SUP>5</SUP> represents a hydrogen atom or substituted or unsubstituted alkyl], or a pharmaceutically acceptable salt thereof or a prodrug thereof is combined with a steroid drug or a steroid combination.