发明名称 |
Isolation of a Dual Cox-2 and 5-Lipoxygenase Inhibitor from Acacia |
摘要 |
The present invention provides a novel method for simultaneously inhibiting the cyclooxygenase COX-2 and 5-lipoxygenase (5-LO) enzymes. The method for the simultaneous dual inhibition of COX-2 and 5-LO is comprised of administering a composition containing an individual and/or a mixture of multiple flavans isolated from a single plant or multiple plants in the Acacia genus of plants to a host in need thereof. The present also includes novel methods for the prevention and treatment of COX-2 and 5-LO mediated diseases and conditions. The method for preventing and treating COX-2 and 5-LO mediated diseases and conditions is comprised of administering to a host in need thereof an effective amount of a composition comprising an individual and/or a mixture of multiple flavans isolated from a single plant or multiple plants in the Acacia genus of plants and a pharmaceutically acceptable carrier. The present invention includes a method for isolating and purifying a composition of flavans having dual specificity for COX-2 and 5-LO from the Acacia genus of plants. |
申请公布号 |
US2006269627(A1) |
申请公布日期 |
2006.11.30 |
申请号 |
US20060457388 |
申请日期 |
2006.07.13 |
申请人 |
UNIGEN PHARMACEUTICALS, INC. |
发明人 |
JIA QI;NICHOLS TIMOTHY C.;RHODEN ERIC E.;WAITE SCOTT |
分类号 |
A61K31/352;A61K36/48;A61K31/33;A61P1/04;A61P15/08;A61P17/02;A61P17/06;A61P19/02;A61P25/04;A61P25/06;A61P29/00;A61P35/00;A61P37/02;A61P43/00 |
主分类号 |
A61K31/352 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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