CELLULAR RECEPTOR FOR VARICELLA-ZOSTER VIRUS, METHODS OF INHIBITING SPREAD OF VARICELLA-ZOSTER AND METHODS OF INCREASING STABILITY AND INFECTIVITY OF THE VIRUS

摘要

A method of identifying an anti-Varicella-zoster (VZV) compound is described. Also described is the receptor for glycoprotein E (gE) comprising insulin degrading enzyme (IDE). Also described is a compound that inhibits cell-to-cell spread of VZV and methods of inhibiting the entry of VZV into a cell. Also described are pharmaceutical compositions for reducing or preventing the cell to cell spread of VZV. Also described is a compound and method for increasing the stability of VZV vaccines and a compound and method for increasing the infectivity of VZV.