Leucinamide derivatives suitable as cathepsin cysteine protease inhibitors

摘要

Leucinamide derivative compounds of formula (I) which are cathepsin cysteine protease inhibitors, particularly inhibitors of cathepsins K, L, S and B are disclosed , wherein the substituents for the variables shown in formula (I) are as defined in the specification. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis, glucocorticoid induced osteoporosis, Paget's disease, abnormally increased bone turnover, periodontal disease, tooth loss, bone fractures, rheumatoid arthritis, osteoarthritis, periprosthetic osteolysis, osteogenesis imperfecta, metastatic bone disease, hypercalcemia of malignancy and multiple myeloma.