Thixotropic gel composition for injectable deposition

摘要

Disclosed is a composition comprising a lactic acid-based polymer; a solvent that forms a polymer solution with said polymer; an amount of an agent mixed with the polymer solution effective to form a thixotropic composition, the solvent being selected from the group consisting of lower alkyl and aralalkyl esters of benzoic acid, said agent being selected from the group consisting essentially of lower alkanols and said amount being less than 15 weight percent of the combined weight of the solvent and the agent; and a beneficial agent. The disclosed compositions are useful for the sustained release of a beneficial subject over time by forming a gel depot when injected into a subject.