发明名称 |
METHODS OF SYNTHESIZING 6-ALKYLAMINOQUINOLINE DERIVATIVES |
摘要 |
The present invention is directed to a method of synthizing compounds of formula (I), wherein X, Z, V, R<SUB>1</SUB>, R<SUB>3</SUB>, R<SUB>4</SUB>, G<SUB>2</SUB>, n, x, y, and z are defined herein. This invention also includes a method of preparing acid compounds of formula (VII), wherein R is H, and R<SUB>4</SUB>, x, y, and z are as defined herein and PG is a protecting group. This invention is also directed to (E) N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(methylamino)-2-butenamide, compositions containing it and methods of using the to treat cancer. |
申请公布号 |
WO2006127203(A2) |
申请公布日期 |
2006.11.30 |
申请号 |
WO2006US15931 |
申请日期 |
2006.04.26 |
申请人 |
WYETH;CHEW, WARREN;RABINDRAN, SRIDHAR, KRISHNA;DISCAFANI-MARRO, CAROYLN;MCGINNIS, JOHN, PATRICK, III;WISSNER, ALLAN;WANG, YOUCHU |
发明人 |
CHEW, WARREN;RABINDRAN, SRIDHAR, KRISHNA;DISCAFANI-MARRO, CAROYLN;MCGINNIS, JOHN, PATRICK, III;WISSNER, ALLAN;WANG, YOUCHU |
分类号 |
C07D215/44;C07C271/22;C07D403/12 |
主分类号 |
C07D215/44 |
代理机构 |
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