发明名称 |
SEVERE ACUTE RESPIRATORY SYNDROME DNA VACCINE COMPOSITIONS AND METHODS OF USE |
摘要 |
The present invention is directed to raising a detectable immune response in a vertebrate by administering in vivo, into a tissue of the vertebrate, at least one polynucleotide comprising one or more regions of nucleic acid encoding a SARS-CoV protein or a fragment, a variant, or a derivative thereof. The present invention is further directed to raising a detectable immune response in a vertebrate by administering, in vivo, into a tissue of the vertebrate, at least one SARS-CoV protein or a fragment, a variant, or derivative thereof. The SARS-CoV protein can be, for example, in purified form. The polynucleotide is incorporated into the cells of the vertebrate in vivo, and an immunologically effective amount of an immunogenic epitope of a SARS-CoV polypeptide, fragment, variant, or derivative thereof is produced in vivo. |
申请公布号 |
WO2005021707(A3) |
申请公布日期 |
2006.11.30 |
申请号 |
WO2004US15512 |
申请日期 |
2004.05.17 |
申请人 |
VICAL INCORPORATED;VILALTA, ADRIAN;EVANS, THOMAS, G.;QUONG, MELANIE, W.;MANTHORPE, MARSTON |
发明人 |
VILALTA, ADRIAN;EVANS, THOMAS, G.;QUONG, MELANIE, W.;MANTHORPE, MARSTON |
分类号 |
A61K31/7088;A61K39/215;A61K39/395;C07K14/165;C07K16/10;C12N;C12N15/50 |
主分类号 |
A61K31/7088 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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