Desmopressin acetate in an orodispersible dosage form that disintegrates in the mouth within 10 seconds

摘要

Good bioavailability of desmopressin can be obtained by means of an orodispersible pharmaceutical dosage form. Preferred dosage forms comprise desmopressin acetate in an open matrix network, which is an inert water-soluble or water-dispersible carrier material in a form adapted for sublingual administration. Desmopressin acetate formulated in this way is useful for voiding postponement, or the treatment or prevention of incontinence, primary nocturnal enuresis (PNE), nocturia or central diabetes insipidus. Peptides other than desmopressin can also be formulated in this way.