发明名称 |
Systems and methods for microarray data analysis |
摘要 |
Clustering is routinely applied in the exploratory analysis of microarray data. Missing entries arise from blemishes on the microarrays. The present invention provides a new method, and computer program and/or computer product thereof to impute missing values. The method involves the steps of clustering microarray data by partitioning the data into a select number of clusters, wherein each data point is iteratively moved from one cluster to another, until two consecutive iterations have resulted in the same partition pattern; obtaining a select number of estimates of the data in the clusters by probabilistic interference; and averaging the select number of estimates to obtain missing values in the microarray data. The method is superior to other imputation models as measured by root mean squared errors.
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申请公布号 |
US2006271300(A1) |
申请公布日期 |
2006.11.30 |
申请号 |
US20040565417 |
申请日期 |
2004.07.29 |
申请人 |
WELSH WILLIAM J;OUYANG MING;LIOY PAUL;GEORGOPOULOS PANOS |
发明人 |
WELSH WILLIAM J.;OUYANG MING;LIOY PAUL;GEORGOPOULOS PANOS |
分类号 |
G01N33/48;G06F;G06F19/20;G06F19/24 |
主分类号 |
G01N33/48 |
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