发明名称 |
Serine proteases with altered sensitivity to activity-modulating substances |
摘要 |
The present invention provides variants of serine proteases of the S1 class with altered sensitivity to one or more activity-modulating substances. A method for the generation of such proteases is disclosed, comprising the provision of a protease library encoding polynucleotide sequences, expression of the enzymes, screening of the library in the presence of one or several activity-modulating substances, selection of variants with altered sensitivity to one or several activity-modulating substances and isolation of those polynucleotide sequences that encode for the selected variants.
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申请公布号 |
US2006269538(A1) |
申请公布日期 |
2006.11.30 |
申请号 |
US20060441635 |
申请日期 |
2006.05.26 |
申请人 |
KOLTERMANN ANDRE;KETTLING ULRICH;HAUPTS ULRICH;COCO WAYNE M;TEBBE JAN;VOTSMEIER CHRISTIAN;SCHEIDIG ANDREAS |
发明人 |
KOLTERMANN ANDRE;KETTLING ULRICH;HAUPTS ULRICH;COCO WAYNE M.;TEBBE JAN;VOTSMEIER CHRISTIAN;SCHEIDIG ANDREAS |
分类号 |
A61K38/48;C07H21/04;C12N9/64;C12P21/06;C40B40/10;C40B50/06 |
主分类号 |
A61K38/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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