发明名称 |
Small interference rna gene therapy |
摘要 |
Gene expression is inhibited in a cell by introducing into the cell a lentiviral vector encoding a siRNA specific for the gene. Lentiviral vectors encoding siRNA specific for a cancer-associated gene inhibited expression of the gene and caused cell death after being introduced into cancer cells. Viral replication in HIV-infected cells was inhibited after introducing a lentiviral vector encoding siRNA specific for HIV genes in into the cells.
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申请公布号 |
US2006269518(A1) |
申请公布日期 |
2006.11.30 |
申请号 |
US20040542461 |
申请日期 |
2004.01.15 |
申请人 |
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. |
发明人 |
CHANG LUNG-JI;HE JIN |
分类号 |
A61K48/00;C12N15/11;C12N15/113;C12N15/867 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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