发明名称 |
COMPOSITIONS FOR INDUCING AN IMMUNE RESPONSE AGAINST HEPATITIS B |
摘要 |
<p>The present invention is directed to a method of inducing an immune response against a hepatitis B antigen (e.g., an antigen from a hepatitis B virus) in a mammal, which comprises administering to the mammal a priming composition (e.g., a DNA plasmid), comprising a source of one or more epitopes of the hepatitis B target antigen; and a boosting composition, comprising a source of one or more epitopes of the hepatitis B target antigen (e.g., a non-replication or replication-impaired poxvirus such as MVA), wherein at least one epitope of the boosting composition is identical to an epitope of the priming composition. The present invention also is directed to a method of inducing an immune response against a hepatitis B antigen (e.g., an antigen from a hepatitis B virus) in a mammal, which comprises administering to the mammal a priming composition (e.g., a DNA plasmid), comprising a source of one or more epitopes of the hepatitis B target antigen. In addition, the present invention is directed to compositions for use in the methods of the present invention.</p> |
申请公布号 |
WO2006125983(A1) |
申请公布日期 |
2006.11.30 |
申请号 |
WO2006GB01902 |
申请日期 |
2006.05.23 |
申请人 |
OXXON THERAPEUTICS LTD;SCHNEIDER, JOERG;CHORLTON, JAMES;PEARCE, GILL;JONES, NICOLA;BROWN, DEAN |
发明人 |
SCHNEIDER, JOERG;CHORLTON, JAMES;PEARCE, GILL;JONES, NICOLA;BROWN, DEAN |
分类号 |
C07K14/02;A61K39/285;A61K48/00;C12N15/85;C12N15/863 |
主分类号 |
C07K14/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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