METHODS OF SYNTHESIZING 6-ALKYLAMINOQUINOLINE DERIVATIVES

摘要

The present invention is directed to a method of synthizing compounds of formula (I): wherein X, Z, V, R₁, R₃, R₄, G₂, n, x, y, and z are defined herein. This invention also includes a method of preparing acid compounds of formula (VII): wherein R is H, and R₄, x, y, and z are as defined herein and PG is a protecting group. This invention is also directed to (E)N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(methylamino)-2-butenamide, compositions containing it and methods of using the to treat cancer.