发明名称 |
GENETIC ASSOCIATION OF POLYMORPHISMS IN THE ATF6-ALPHA GENE WITH INSULIN RESISTANCE PHENOTYPES |
摘要 |
The present invention relates to polymorphisms in the ATF6-alpha gene or locus which show genetic association with insulin resistance phenotypes, such as metabolic syndrome and type 2 diabetes. The present invention further relates to methods of genetic diagnosis of insulin resistance phenotypes comprising testing polymorphisms in the ATF6-alpha gene or locus and to reagents suitable for use in such methods. Further the invention relates to screening methods for compounds modulating the expression and/or function of ATF6-alpha gene and/or protein, which are useful in treatment and/or prevention of insulin resistance phenotypes. |
申请公布号 |
CA2609229(A1) |
申请公布日期 |
2006.11.30 |
申请号 |
CA20062609229 |
申请日期 |
2006.05.05 |
申请人 |
UNIVERSITEIT MAASTRICHT |
发明人 |
VLIETINCK, ROBERT;AYOUBI, TORIK A.Y.;MEEX, STEVEN J.R.;VAN DER KALLEN, CARLA J.H.;VAN GREEVENBROEK, MARLEEN M.J.;DE BRUIN, TJERK W.A. |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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