| 摘要 |
PROBLEM TO BE SOLVED: To provide an agent that can sufficiently develop the sleep-ameliorating action of the histamine H1 receptor antagonist having reduced side effect. SOLUTION: The sleep-ameliorating agent comprises a histamine H1 receptor antagonist, (at least one selected from the group consisting of Diphenhydramine, Azatadine, Brompheniramine, Cetirizine, Chlorpheniramine, Clemastine, Cyproheptadine, Desloratadine, Dexchlorpheniramine, Dimenhydrinate, Doxylamine, Fexofenadine, Hydroxyzine, Loratadine, Phenindamine, and their acid adduct salts) and vitamin B<SB>12</SB>s (at least one selected from the group consisting of Cyanocobalamin, Hydroxocobalamin and Mecobalamine). The sleep-ameliorating agent is useful for treatment or prevention of hypnagogic disorder, deep sleep disorder, middle wakening, or early wakening. COPYRIGHT: (C)2007,JPO&INPIT
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