High throughput glycan analysis for diagnosing and monitoring rheumatoid arthritis and other autoimmune diseases

摘要

One can identify and quantify one or more glycosylation markers of an autoimmune disease such as rheumatoid arthritis by utilizing quantitative HPLC analysis of glycans which have been released from unpurified glycoproteins. The unpurified glycoproteins can be total glycoproteins or a selection of the total glycoproteins. The identified glycosylation marker can be utilized for monitoring and/or diagnosing the autoimmune disease.