| 发明名称 |
METHOD FOR PRODUCING A PRECURSOR OF THE ANTICHOLINERGIC AGENT TIOTROPIUM BROMIDE |
| 摘要 |
Tiotropium bromide is produced from di-(2-thienyl)-glycolic acid tropenol ester in a two step process comprising oxidation and subsequent quaternisation. Production of tiotropium bromide (I) comprises oxidation of the di-(2-thienyl)-glycolic acid tropenol ester (II) and quaternisation of the resulting di-(2-thienyl)-glycolic acid scopine ester (III) with methyl bromide. |
| 申请公布号 |
PT1426373(E) |
申请公布日期 |
2006.11.30 |
| 申请号 |
PT20040005241T |
申请日期 |
2001.12.12 |
| 申请人 |
BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG |
发明人 |
ROLF BANHOLZER;HELMUT MEISSNER;MANFRED GRAULICH;SVEN LUETTKE;ANDREAS MATHES;PETER SPECHT;WOLFGANG BROEDER |
| 分类号 |
C07D451/10;A61K31/46;A61P11/06;A61P11/08;A61P25/00;A61P43/00;C07D451/06 |
主分类号 |
C07D451/10 |
| 代理机构 |
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