METHODS OF USING RAMAN SPECTRAL INFORMATION IN DETERMINING ANALYTE CONCENTRATIONS

摘要

A non-invasive method of determining the concentration of an analyte uses Raman spectral information. A high-intensity, narrow band of light (10) is applied to one side (12a) of skin tissue (12) . The high-intensity light (10) enters the skin tissue and generates a Raman signal (16) . A reflective material (22) is placed in a location nearest the other side (12b) of skin tissue (12) . The reflective material (22) is located generally opposite of the entry (A) of the applied high-intensity light (10) . The high-intensity light (10) and the Raman signal (20) that pass through the skin tissue (12) are reflected back into the skin tissue (12) via the reflective material (22) . The Raman signal (16,20) is collected and the analyte concentration is determined using the collected Raman signal (16,20) .