| 摘要 |
Disclosed is a process for the preparation of an epiK5-N,O-oversulfate-derivative and compounds formed by said process, characterized in that: (a) An epiK5-N-sulfate-derivative in acidic form is treated with a tertiary or quaternary organic base, letting the reaction mixture stand for a time period of 30-60 minutes at a pH of approximately 7 and its salt is isolated with said organic base. (b) Said salt of organic base of said epiK5-N-sulfate-derivative is treated with an O-sulfation reagent in the conditions of O-oversulfation. (c) A salt of a tertiary or quaternary organic base of epiK5-amine-O-oversulfate-derivative thus obtained is treated with a reagent of N-sulfation and the epiK5-N,O-oversulfate-derivative thus obtained is isolated. Additionally disclosed are epiK5-N,O-oversulfate-derivitaves having a mean molecular weight from 2,000 to 45,000 and a sulfation degree of at least 4, LMW-epiK5-amine-O-oversulfates and derivatives thereof, LMW-epiK5-N-sulfates and methods of producing them.
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