发明名称 |
PREPARATION OF PH-RESPONSIVE POLYMER-LIPOSOME COMPLEXES WITH VARIOUS HYDROPHOBIC BIOACTIVE MATERIALS AND THE COMPOSITION OF SKIN EXTERNAL APPLICATION CONTAINING THE SAME |
摘要 |
Provided are a polymer-liposome nanocomposite which is remarkably improved in the stability against various salts and cosmetic preparations and contains various bioactive ingredients, and its preparation method. The polymer-liposome nanocomposite comprises 1-50 wt% of a poly(methacrylic acid-co-n-alkyl methacrylate) random copolymer represented by the formula 1; and 50-99 wt% of a lipid dual layer which contains a useful bioactive ingredient, wherein n is 11-22; and x:y is 85:15 to 70:30 by mol. Preferably the poly(methacrylic acid-co-n-alkyl methacrylate) random copolymer has a number average molecular weight of 10,000-50,000 and a particle size of 100-400 nm. The method comprises the steps of mixing the copolymer of the formula 1, a lipid and a bioactive ingredient in an organic solvent miscible with water to dissolve them at 50-70 deg.C; mixing the obtained mixture with the heated water of 50-70 deg.C to disperse firstly with a homogenizer; and preparing nanoparticles from the mixture by using a homogenizer.
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申请公布号 |
KR100654102(B1) |
申请公布日期 |
2006.11.29 |
申请号 |
KR20050135409 |
申请日期 |
2005.12.30 |
申请人 |
AMOREPACIFIC CORPORATION |
发明人 |
LIM, HYUNG JUN;CHO, EUN CHUL;KIM, JUN OH;CHANG, IH SEOP |
分类号 |
C08F8/00;A61K8/00 |
主分类号 |
C08F8/00 |
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