发明名称 |
Peptide fragment having cytotoxicity-inhibitory activity and screening method for peptide fragment having said cytotoxicity-inhibitory activity |
摘要 |
A peptide fragment or a series of peptide fragments containing one or more selenocysteine that has a lowered toxicity than selenocystine and that exhibits a cytotoxicity-inhibitory activity. The peptide fragment or a series of peptide fragments according to the present invention has preferably the amino acid sequence from 260th to 362nd amino acid residues from the C-terminal of selenoprotein P, or said amino acid sequence with one or several amino acid residues therein being deleted, substituted or added, or a partial sequence of either of the above amino acid sequences, or an amino acid sequence comprising as a part any of the above amino acid sequences. A screening method for a peptide fragment having the cytotoxicity-inhibitory activity is also provided.
|
申请公布号 |
EP1726649(A2) |
申请公布日期 |
2006.11.29 |
申请号 |
EP20060010000 |
申请日期 |
2002.05.10 |
申请人 |
JURIDICAL FOUNDATION THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE;HISAMITSU PHARMACEUTICAL CO., INC. |
发明人 |
HIRASHIMA, MASAKI;NARUSE, TAKESHI;MAEDA, HIROAKI;NOZAKI, CHIKATERU;GOTO, TAKESHI;AKIYAMA, KATSUHIKO;HATTORI, WATARU |
分类号 |
C12N15/09;C07K14/47;C12Q1/02;G01N33/50 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|