发明名称 |
Method for the provision, identification and selection of proteases with altered sensitivity to activity-modulating substances |
摘要 |
<p>The present invention provides a method for the selection of proteases with altered sensitivity to one or more activity-modulating substances. The method combines the provision of a protease library encoding polynucleotide sequences, expression of the enzymes, screening of the library in the presence of one or several activity-modulating substances, selection of variants with altered sensitivity to one or several activity-modulating substances and isolation of those polynucleotide sequences that encode for the selected variants.</p> |
申请公布号 |
EP1726643(A1) |
申请公布日期 |
2006.11.29 |
申请号 |
EP20050104543 |
申请日期 |
2005.05.27 |
申请人 |
DIREVO BIOTECH AG |
发明人 |
KOLTERMANN, ANDRE;KETTLING, ULRICH;HAUPTS, ULRICH;COCO, WAYNE;TEBBE, JAN;VOTSMEIER, CHRISTIAN;SCHEIDIG, ANDREAS |
分类号 |
C12N15/00;C12N9/00;C12Q1/37 |
主分类号 |
C12N15/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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