Network-based approaches to identifying significant molecules based on high-throughput data analysis

摘要

Methods, systems and computer readable media for network-based identification of significant molecules, for which at least one biological network (100) is provided to include significant molecules to be identified. A node in the network is identified. A member-specific sub-network containing nodes connected to the identified node is identified for L levels of nearest neighbors, wherein L is a positive integer, and a connectivity score (214) is calculated for the molecule represented by the identified node based on significance scores (210, 308) of each node contained in the member-specific sub-network. These steps are repeated for other nodes in the network.