发明名称 |
Iontophoretic delivery of rotigotine for the treatment of Parkinson's disease |
摘要 |
By using a composition comprising rotigotine and at least one chloride salt in a concentration of 1 to 140 mmol/l, the composition having a pH of 4 to 6.5 in a iontophoretic device for the treatment of Parkinson's disease, it became possible to obtain a rotigotine flux across the human stratum corneum which was higher than the one previously obtained with conventional passive diffusion systems. |
申请公布号 |
ZA200503750(B) |
申请公布日期 |
2006.11.29 |
申请号 |
ZA20050003750 |
申请日期 |
2005.05.10 |
申请人 |
SCHWARZ PHARMA AG. |
发明人 |
WOLFF, HANS-MICHAEL;LI, GAI LING;BOUWSTRA, JOHANNA AALTJE;NUGROHO, AKHMAD KHARIS |
分类号 |
A61K;A61K9/00;A61K31/381;A61K47/00 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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