发明名称 METHODS OF PREPARING 2-[2-(3-METHOXYPHENYL)ETHYL]PHENOL AND INTERMEDIATE THEREOF UNDER PALLADIUM CATALYSIS
摘要 Provided is a method for preparing 2-[2-(3-methoxyphenyl)ethyl]phenol and an intermediate thereof using a palladium catalyst, and thus 2-[2-(3-methoxyphenyl)ethyl]phenol and the intermediate thereof are produced in higher yield according to the simpler reaction process. The method for preparing 2-[2-(3-methoxyphenyl)ethyl]phenol represented by the following formula 1 comprises the steps of: (i) forming a (methoxyphenyl)ethynylphenol derivative represented by the following formula 2a by reacting a halogen-containing phenol derivative with an acetylene compound under a palladium catalyst and an auxiliary catalyst; and (ii) dissolving the (methoxyphenyl)ethynylphenol derivative of the formula 2a in ethanol, adding Pd/C thereto, and reducing the prepared solution under a hydrogen gas. In the formula 2a, R1 is selected from the group consisting of H and a benzyl group.
申请公布号 KR20060121630(A) 申请公布日期 2006.11.29
申请号 KR20050044301 申请日期 2005.05.25
申请人 PHARMACOSTECH CO., LTD. 发明人 KIM, JAE WEON;RYU, HYUNG CHUL
分类号 C07C37/11 主分类号 C07C37/11
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