发明名称 |
Latent fusion protein |
摘要 |
The present invention provides a method for providing latency to a pharmaceutically active agent. The method has application in overcoming the toxic effect of systemic administration of potent biological agents. The method comprises associating a fusion protein comprising a latency associated peptide and a proteolytic cleavage site with a pharmaceutically active agent. The fusion protein also has application in providing site specific activation to a latent pharmaceutically active agent.
|
申请公布号 |
US7141392(B2) |
申请公布日期 |
2006.11.28 |
申请号 |
US20040753181 |
申请日期 |
2004.01.07 |
申请人 |
QUEEN MARY AND WESTFIELD COLLEGE |
发明人 |
CHERNAJOVSKY YUTI;DREJA HANNA STINA;ADAMS GILLIAN |
分类号 |
C07H21/04;A61K38/00;C07K14/495;C07K14/565;C12N15/62;C12N15/85;C12N15/86 |
主分类号 |
C07H21/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|