| 摘要 |
A compound of formula (I) wherein R1, R2, R3, R4 and Q are as defined above, are useful in the treatment of arthritis (including osteoarthritis and rheumatoid arthritis), cancer and other diseases. In addition, the compounds of the present invention may be used in combination therapy with standard no n- steroidal anti-inflammatory drugs (NSAID's), COX-2 inhibitors and analgesics , and in combination with cytotoxic drugs such as adriamycin, daunomycin, cis- platinum, etoposide, taxol, taxotere and other alkaloids, such as vincristin e, in the treatment of cancer.
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