发明名称 |
PROCESS FOR PREPARATION OF A SALT OF .GAMMA.-(PIPERIDYL) BUTYRIC ACID WITH AN ACID |
摘要 |
At least one of a Rh catalyst, a Pd catalyst or a Ru catalyst is used as a catalyst in preparing the salt of .gamma.-(piperidyl)-butyric acid (2) by hydrogenating the salt of .gamma.-(pyridyl)butyric acid (1) [preferably the salt of y-(pyridyl)butyric acid (1) obtained in the undermentioned steps (a) and (b) and containing not more than 3% by weight of salt of bis(pyridylethyl)acetic acid (3)] in a solvent in the presence of a catalyst: (a) reacting the vinylpyridine (4) with the diester of malonic acid (5) in the presence of a base to give the 2-(pyridylethyl)malonic acid diester (6), and (b) hydrolyzing and decarboxylating the 2- (pyridylethyl)malonic acid diester (6) obtained in the step (a) in an acidic aqueous solution to give the salt of .gamma.-(pyridyl)butyric acid (1).
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申请公布号 |
CA2239138(C) |
申请公布日期 |
2006.11.28 |
申请号 |
CA19972239138 |
申请日期 |
1997.10.07 |
申请人 |
KOEI CHEMICAL CO., LTD. |
发明人 |
SAKAI, TOSHITO;NAGAOKA, MASAYO;KANNO, KEN |
分类号 |
C07D211/34;C07D213/55 |
主分类号 |
C07D211/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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