BIOACTIVE FUSION PROTEINS AND TREATMENT OF PREEXISTING TUMOR

摘要

PROBLEM TO BE SOLVED: To provide bioactive fusion proteins which comprise at least two polypeptide monomers (chains of amino acids) joined through a polypeptide linker, and a production method thereof.

SOLUTION: Disclosed are a DNA comprising DNA encoding IL-12 p35 subunit, DNA encoding a polypeptide linker and DNA encoding IL-12 p40 subunit, wherein the DNA encoding the polypeptide linker is positioned between the DNA encoding the IL-12 p35 subunit and the DNA encoding the IL-12 p40 subunit and wherein expression of the DNA results in production of a bioactive IL-12 fusion protein comprising the IL-12 p35 subunit and the IL-12 p40 subunit joined by the encoded polypeptide linker.

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