TRI-, TETRA-SUBSTITUTED-3-AMINOPYRROLIDINE DERIVATIVE

摘要

It is intended to provide quinolone type synthetic antibacterial agents havi ng a potent antibacterial activity against a broad scope of gram-positive and gram-negative bacteria and a high safety and remedies for infections. A compound represented by the following general formula (I), its salt or hydra te thereof: I wherein R1 and R2 represent each hydrogen, etc.; R3 represents C1 -6 alkyl, etc.; R4 and R5 independently represent each hydrogen, C1-6 alkyl, etc., provided that R4 and R5 are not hydrogen atoms at the same time, and t he above substituents R4 and R5 may be united and form a spiro ring structure structure together with the pyrrolidine ring; R6 and R7 independently represent each hydrogen or C1-6 alkyl; R8 represents a C1-6 haloalkyl group, etc.; X1 represents hydrogen or halogen; and A represents a nitrogen atom or a partial structure represented by the following general formula (II).