发明名称 |
MODULATORS OF ALPHA-SYNUCLEIN TOXICITY |
摘要 |
Disclosed are genes that, when overexpressed in cells expressing alpha-synuclein, either suppress or enhance alpha-synuclein mediated cellular toxicity. Compounds that modulate expression of these genes or activity of the encoded proteins can be used to inhibit alpha-synuclein mediated toxicity and used to treat or prevent synucleinopathies such as Parkinson's disease. Also disclosed are methods of identifying inhibitors of alpha-synuclein mediated toxicity. |
申请公布号 |
CA2608198(A1) |
申请公布日期 |
2006.11.23 |
申请号 |
CA20062608198 |
申请日期 |
2006.05.12 |
申请人 |
WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH |
发明人 |
GITLER, AARON D.;LINDQUIST, SUSAN L.;CASHIKAR, ANIL |
分类号 |
A61K38/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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