摘要 |
Herpesvirus entry mediator (HVEM) is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and acts as a molecular switch that modulates T cell activation by propagating positive signals from the TNF related ligand, LIGHT (p30, TNFSF14), or inhibitory signals through the immunoglobulin superfamily member, B and T lymphocyte attenuator (BTLA). A novel binding site for BTLA is disclosed, located in cysteine-rich domain-1 of HVEM. BTLA binding site on HVEM overlaps with the binding site for the Herpes Simplex virus-1 envelope glycoprotein D (gD), but is distinct from where LIGHT binds, yet gD inhibits the binding of both ligands. A BTLA activating protein present in human cytomegalovirus is identified as UL144. UL144 binds BTLA, but not LIGHT, and inhibits T cell proliferation. |
申请人 |
LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY;CHEUNG, TIMOTHY, C.;HUMPHREYS, IAN, R.;POTTER, KAREN, G.;BENEDICT, CHRISTOPHER, A.;WARE, CARL, F.;DE TREZ, CARL;CROFT, MICHAEL;KRONENBERG, MITCHELL |
发明人 |
CHEUNG, TIMOTHY, C.;HUMPHREYS, IAN, R.;POTTER, KAREN, G.;BENEDICT, CHRISTOPHER, A.;WARE, CARL, F.;DE TREZ, CARL;CROFT, MICHAEL;KRONENBERG, MITCHELL |