发明名称 |
4, 6-DIAMINO-[1,7] NAPHTHYRIDINE-3-CARBONITRILE INHIBITORS OF TPL2 KINASE AND METHODS OF MAKING AND USING THE SAME |
摘要 |
<p>The present invention provides compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>3</SUP>, R<SUP>4</SUP>, R<SUP>5</SUP>r<SUP>6</SUP>, m and n are defined as described herein. The invention also provides methods of making the compounds of formula (I), and methods of treating inflammatory diseases, such as rheumatoid arthritis, in a mammal comprising administering a therapeutically effective amount of a compound of formula (I) to the mammal.</p> |
申请公布号 |
CA2608362(A1) |
申请公布日期 |
2006.11.23 |
申请号 |
CA20062608362 |
申请日期 |
2006.05.17 |
申请人 |
WYETH |
发明人 |
POWELL, DENNIS WILLIAM;GREEN, NEAL JEFFREY;CUOZZO, JOHN WILLIAM;LIN, LIH-LING;GOPALSAMY, ARIAMALA;JANZ, KRISTIN MARIE;THOMASON, JENNIFER R.;GAVRIN, LORI KRIM;TAM, STEVE Y.;HU, YONGHAN;KAILA, NEELU |
分类号 |
C07D471/04;A61K31/4375 |
主分类号 |
C07D471/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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