BETA-METHYLCARBAPENEM DERIVATIVES, PREPARATION THEREOF AND ANTIBIOTIC COMPOSITION COMPRISING THE SAME

摘要

Provided is a beta-methylcarbapenem derivative showing excellent antibacterial effect on resistant bacteria such as methicillin resistant Staphylococcus Aureus(MRSA) and having strong antibacterial effect on Gram positive bacillus so as to be usefully used as antibiotics for incurable resistant bacteria inflammations. The beta-methylcarbapenem derivative is represented by the formula(1) and is prepared by reacting a 2-diphenylphosphoryloxy carbapenem derivative represented by the formula(2) with a cyclopentano pyridineazetidine-3-yl-thiol derivative represented by the formula(3) to prepare a carbapenem ester derivative represented by the formula(4) and then removing a protecting group(R1) from the compound represented by the formula(4). In the formulae, R1 is a carboxy protecting group, and M is H or zwitterion forming a physiologically acceptable salt.