This invention provides glucuronidated nebivolol metabolites and pharmaceutical compositions of glucuronidated nebivolol for treatment of cardiovascular diseases. In addition, this invention also provides compositions comprising nebivolol and/or at least one glucuronidated metabolite of nebivolol and/or at least one other active compound in a pharmaceutically acceptable carrier. This invention also provides methods of treating and/or preventing vascular diseases, by administering at least one glucuronidated metabolite of nebivolol that is capable of releasing a therapeutically effective amount of nitric oxide to a targeted site affected by the vascular disease.
申请公布号
WO2006083780(A3)
申请公布日期
2006.11.23
申请号
WO2006US03253
申请日期
2006.01.30
申请人
MYLAN LABORATORIES, INC.;O'DONNELL, JOHN, P.;OWENS, WALTER;DUNCAN, JOSEPH;SHAW, ANDREW
发明人
O'DONNELL, JOHN, P.;OWENS, WALTER;DUNCAN, JOSEPH;SHAW, ANDREW