Process for the preparation of aryl-piridyl compounds

摘要

A method is described for the preparation of aryl-pyridine compounds of formula (I) by cross-coupling reaction, promoted by catalytic systems based on palladium or nickel between compounds of formula (II) and (III) in which:-Met represents Mg or Zn,-Y represents Cl, Br, I or acetoxy,-Z represents I, Br, Cl, triflate, sulphonate, phosphate,-R₁, R₂, R₃, R₄, which are the same as one another or different, represent hydrogen, a linear and/or branched C₁-C₄ alkyl, and/or an aryl, and/or a heteroaryl, or R₁ and R₂ and/or R₃ and R₄, taken together, form a C₃-C₈ ring, an aryl and/or a heteroaryl,-A represents -COR₅ where R₅ represents hydrogen, a linear and/or branched C₁-C₄ alkyl, and/or an aryl, and/or a heteroaryl, or-A represents -CR_s5(OR₆)(OR₇) where R₅ has the meaning described above and R₆ and R₇, which are the same as one another or different, represent a linear and/or branched C₁-C₄ alkyl, and/or an aryl, and/or a heteroaryl, or R₆ and R₇, joined together, represent a C₁-C₈ alkyl or alkenyl.