MEDICINAL COMPOSITIONS AND COMBINATIONS

摘要

Treatment of hyperlipemia or arteriosclerosis either with a composition containing (A) a 3-hydroxy-3- methylglutaryl -coenzyme A reductase inhibitor or a salt thereof and/or ezetimibe or a prodrug or salt thereof and (B) a compound represented by the general formula (1) or a salt thereof or by coadministration of the components (A) and (B) is efficacious even for patients whose blood cholesterol levels could not be satisfactorily lowered with current therapeutic drugs to the target level of treatment, particularly patients in whom coronary heart diseases have appeared. (1) (wherein A is a substituted or unsubstituted pyridine ring; Y is a substituted or unsubstituted aromatic group or the like; R1 is hydrogen, substituted or unsubstituted alkyl, or the like; R2 is hydrogen or lower alkyl; R3 is lower alkyl; and Z is hydroxy, amino, or the like).